the role of parathyroid hormone on stature in major beta-thalassemic patients

the role of parathyroid hormone on stature in major beta-thalassemic patients   gr. moshtaghi kashanian phd 1 , a. ahmadi md2, mm. hayat bakhsh md3   1- assistant professor, dept. of biochemistry, faculty of medicine, university of medical sciences, kerman, iran   2- professor of pediaterics, university of medical sciences, kerman, iran   3- assistant professor of internal medicine, faculty of medicine, university of medical sciences, kerman, iran   background: bone changes are typical complications of thalassaemia major, with unknown pathogenesis. there are only a few studies concerning mineral metabolism and parathyroid hormone (pth) level in the patients whit this disorder, but the number of cases are limited and results are controversial. since there are many major beta-thalassemic patients in kerman area, the present study investigated the related factors in bone metabolism of these patients including pth, ionized calcium, inorganic phosphate, and alkaline phosphatase level in patients with different age.   material and methods: in a cross sectional study, blood samples (5ml) were collected from 200 patients refferiry to the thalassemia clinic for blood transfusion. the patients were divided into five different age groups (